The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
Differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concernArticle Published on 2022-09-162022-11-16 Journal: Science Advances [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 canonical coronavirus coronavirus disease COVID-19 CSS Cytokine storm syndrome Genetic hemorrhages Host immune response hyperinflammation Inflammasome Inflammation less life-threatening Local long-lasting Macrophage mechanism neutrophil pandemic proinflammatory proinflammatory activity promoted Protein recruitment rescued SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant spike systemic hyperinflammation variant variants variants of concern zebrafish [DOI] 10.1126/sciadv.abo0732 PMC 바로가기
SARS-CoV-2 can infect human embryosArticle Published on 2022-09-142022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] ACE2 antibody canonical Cell cell entry cells co-expressed COVID-19 COVID-19 pandemic Effect Embryo embryogenesis embryos Factor fluorescent glycoprotein Health human tissue identify immunofluorescence implicated implication infect Infection observé organ pandemic Pregnancy reporter reproductive resulting RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection spike Spread susceptibility susceptible Symptom target tissue TMPRSS2 viral entry virions pseudotyped [DOI] 10.1038/s41598-022-18906-1 PMC 바로가기
A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination감염 및 백신 접종 후 표적화된 SARS-CoV-2 스파이크의 SD1 도메인에 대한 중화 에피토프Article Published on 2022-08-232022-09-12 Journal: Cell Reports [Category] SARS, 진단, [키워드] acute respiratory syndrome antibody bind canonical coronavirus CP: Immunology CP: Microbiology Cryo-electron microscopy cryo-EM cryogenic electron microscopy domain elicited epitope glycoprotein hydrogen-deuterium exchange identify Immune escape Infection N-terminal domain neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing epitope NTD omicron predominant prefusion RBD Receptor binding domain Region Research SARS-CoV-2 SARS-CoV-2 spike shown spike subdomain 1. target the SARS-CoV-2 vaccination Vaccine development while [DOI] 10.1016/j.celrep.2022.111276 PMC 바로가기 [Article Type] Article
Identification of Potential ACE2-Derived Peptide Mimetics in SARS-CoV-2 Omicron Variant Therapeutics using Computational Approaches전산 접근법을 사용한 SARS-CoV-2 오미크론 변이 치료제의 잠재적 ACE2 유래 펩티드 모방체 식별Article Published on 2022-08-182022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, [키워드] accelerated ACE2 Amino acid amino acids Analysis angiotensin Angiotensin converting enzyme-2 binding binding affinity canonical COVID-19 pandemic dependent on effort event Health Health Organization human infection identification indicated infection rate inhibit inhibition Interaction molecular dynamics Molecular dynamics simulation Mutation omicron path peptide peptides Potential RBD RBDs receptor Receptor binding domain SARS-CoV-2 therapeutic Therapeutics variant variants viral infection VoC WHO World Health Organization [DOI] 10.1021/acs.jpclett.2c01155 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis single-cell analysis. the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent originSARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology. [DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article
The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9bDeubiquitinase USP29는 ORF9b의 프로테아좀 분해를 방지하여 SARS-CoV-2 독성을 촉진합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Antiviral biological processes canonical carboxyl caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense Degradation deubiquitinase deubiquitination. develop E3 ubiquitin ligase E3 ubiquitin ligases effort eGFP enhancement Evidence Health healthy help Host host defense hosts IFN IFN-I IKKɑ Immunity inhibit inhibiting innate immune response Intensive interact Interaction IκB mechanisms Modification mRNA level NF-κB NF-κB activation Orf9b Particles pathogen pathogenicity pathway Prevent Preventing proliferation proteasomal proteasome Protein regulate Regulation Replication replication-competent SARS-CoV-2 restrict resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Signaling subsequent Transcription Type I IFN type I interferon ubiquitin USP29 viral infections virulence [DOI] 10.1128/mbio.01300-22 PMC 바로가기 [Article Type] Article
Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19보존된 비정규 항원 및 풍토성 코로나바이러스를 표적으로 하는 항체는 심각한 COVID-19에서 유리한 결과와 연관됩니다Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis antibody antibody profiling Antigen antigenic association canonical cellular Cellular and humoral responses conserved coronavirus coronavirus Coronaviruses COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity defined disease domain Endemic Endemic coronaviruses healthy control Humoral response immunology less membrane Microbiology molecular non-canonical antigens nsp13 Nsp3 nucleocapsid ORF3a ORF8 outcome predict predictor profile profiles Protein Receptor-binding domain respiratory SARS-CoV-2 severe COVID-19 severe COVID-19 patients severity Specificities specificity survival systems immunology. Viral Viral antigen viral antigens while [DOI] 10.1016/j.celrep.2022.111020 PMC 바로가기 [Article Type] Article
SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 OutcomeCovid-19 결과의 예측에서 SCD14-ST 및 신세대 염증 바이오 마커Article Published on 2022-06-132022-08-31 Journal: Biomolecules [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] addition Biomarker Biomarkers canonical clinical feature Clinical features COVID-19 COVID-19 mortality COVID-19 positive patients CRP cytokine Cytokine storm Cytokines cytokines IL-6 died discharged disease Generation ICU ICU Patients IL-10 IL-6 immune immune biomarkers Infection inflammatory biomarkers Inflammatory marker inflammatory markers inflammatory parameters Laboratory Longitudinal evaluation longitudinal study New new infection outcome Patient plasma-EDTA predict prediction prediction of disease. prognostic SARS-CoV-2 SCD14-ST severity significantly higher suPAR the disease to define were measured [DOI] 10.3390/biom12060826 PMC 바로가기 [Article Type] Article